Prognostic value of assessment of glial cell line-derived neurotrophic factor in ischemic stroke patients

Objective. The aim of the study was to estimate prognostic value GDNF in acute IS patients. Glial neurotrophic factor (GDNF) is a neuropeptide, which promotes proliferation and differentiation cells central peripheral nervous system, possesses antihypoxic neuroprotective properties ischemic stroke (IS).
 Materials methods. 50 patients with first-ever were examined at National Institutes Health Stroke Scale (NIHSS); modified Rankin scale used on admission hospital, 7 14 days after stroke. plasma level measured first 48 hours onset. analyzed by commercially available ELISA kit. comparison group included 20 healthy persons.
 Results. average (3.4 [2.8; 5.0] pg/ml) significantly higher than individuals (2.8 [2.6; 2.9] pg/ml), p = 0.02.
 risk unfavourable functional outcome day onset 2.8-fold those whose increased 7th disease more 30% compared its (RR 2,8; 95% CI [1,45,7]).
 less 2.9 pg/ml associated high death during 6,7; [1,530,5]).
 Conclusions. Plasma concentrations have predictive for unfavorable period IS.